Are structural analogues to bisphenol A safe alternatives?

14 May 2014

Bisphenol A (BPA) is a chemical with widespread human exposure suspected of causing low-dose effects. A need for developing alternatives to BPA exists. Structural analogues of BPA have been detected in foods and humans. Due to the structural analogy of the alternatives, there is a risk of effects similar to BPA.
The aim was to elucidate and compare the hazards of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS) and 4-cumylphenol (HPP) to BPA. Interference with the endocrine system was the predominant effect of the test compounds. Substitution of BPA with these structural analogues should be carried out with caution (Toxicological Sciences, 22 February 2014).
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