Polycyclic aromatic hydrocarbons in rubber packaging
Polycyclic aromatic hydrocarbons (PAHs) in rubber packaging used for pharmaceutical formulations and in parenteral products stored in containers with rubber stoppers were investigated.
The rubber materials were shown to contain 12 PAHs, in concentrations ranging from 0.25-3.31 µg/g. Only 1 of 18 samples (11 amino acid solutions and 7 lipid emulsions) was uncontaminated. The most prevalent contaminants were pyrene, benzo[a]pyrene, and fluoranthene. The total PAH concentrations in the samples ranged from 0.11-5.96 µg/mL. Components of parenteral nutrition may be contaminated with PAHs, and rubber stoppers represent a potential source of these contaminants (JPEN, 15 March 2016).
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